The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle |
| |
Authors: | Ates Kenan Yang Shi Yu Orrell Richard W Sinanan Andrea C M Simons Paul Solomon Andrew Beech Steven Goldspink Geoffrey Lewis Mark P |
| |
Institution: | Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, University College London, UK. |
| |
Abstract: | The effects of muscle splice variants of insulin-like growth factor I (IGF-I) on proliferation and differentiation were studied in human primary muscle cell cultures from healthy subjects as well as from muscular dystrophy and ALS patients. Although the initial numbers of mononucleated progenitor cells expressing desmin were lower in diseased muscle, the E domain peptide of IGF-IEc (MGF) significantly increased the numbers of progenitor cells in healthy and diseased muscle. IGF-I significantly enhances myogenic differentiation whereas MGF E peptide blocks this pathway, resulting in an increased progenitor (stem) cell pool and thus potentially facilitating repair and maintenance of this postmitotic tissue. |
| |
Keywords: | Muscle stem Satellite cells ALS Muscular dystrophy Insulin-like growth factor I Mechano growth factor |
本文献已被 ScienceDirect PubMed 等数据库收录! |