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A physical model for the condensation and decondensation of eukaryotic chromosomes
Authors:Mozziconacci Julien  Lavelle Christophe  Barbi Maria  Lesne Annick  Victor Jean-Marc
Institution:Cell Biology and Cell Biophysics Programme, European Molecular Biology Laboratory, Heidelberg, Germany. mozzicon@embl.de
Abstract:During the eukaryotic cell cycle, chromatin undergoes several conformational changes, which are believed to play key roles in gene expression regulation during interphase, and in genome replication and division during mitosis. In this paper, we propose a scenario for chromatin structural reorganization during mitosis, which bridges all the different scales involved in chromatin architecture, from nucleosomes to chromatin loops. We build a model for chromatin, based on available data, taking into account both physical and topological constraints DNA has to deal with. Our results suggest that the mitotic chromosome condensation/decondensation process is induced by a structural change at the level of the nucleosome itself.
Keywords:DNA  Nucleosome  Chromatin fiber  Chromosome  Quantitative biology  Topology
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