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The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc
Authors:Kalra Neetu  Kumar Vijay
Institution:Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India.
Abstract:The HBx protein of hepatitis B virus is involved in deregulation of cell cycle and development of hepatocellular carcinoma. Since c-Myc also plays an important role in cell proliferation and tumor development, we studied its regulation by HBx in a human hepatoma cell line. Co-expression of HBx and c-Myc resulted in increased stability of intracellular c-Myc. HBx blocked the ubiquitination of Myc through a direct interaction with the F box region of Skp2 and destabilization of the SCF(Skp2) complex. We suggest that sustained presence of c-Myc combined with mitogenic activity inherent to HBx may be associated with cell cycle deregulation and transformation.
Keywords:β-TrCP  β-transducin repeat-containing protein  DN  dominant negative  HBV  hepatitis B virus  HBx  X protein of HBV  IgH  Immunoglobulin heavy chain  HA  haemagglutinin  HCC  hepatocellular carcinoma  LRR  leucine-rich repeat  SCF  Skp1-Cullin1-F box protein  SDS-PAGE  SDS-polyacrylamide gel electrophoresis  Ub  ubiquitin
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