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Suppression of metastases of small cell lung cancer cells in mice by a peptidic CXCR4 inhibitor TF14016 |
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| Authors: | Yasushi Otani Takashi Kijima Satoshi Kohmo Shinya OishiToshiyuki Minami Izumi NagatomoRyo Takahashi Haruhiko HirataMayumi Suzuki Koji InoueYoshito Takeda Hiroshi KidaIsao Tachibana Nobutaka FujiiAtsushi Kumanogoh |
| Institution: | a Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan b Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan c Department of Immunopathology, Immunology Frontier Research Center, Osaka University, Osaka, Japan |
| Abstract: | CXCL12 is a chemokine essential for the organ-specific spread of a variety of cancers including small cell lung cancer (SCLC). Here, we examined the anti-metastatic efficacy of TF14016, a small peptidic inhibitor of CXCL12 receptor CXCR4, in SCLC. Treatment of mice with TF14016 significantly suppressed pulmonary metastases of CXCR4-expressing SCLC in size and number. Furthermore, histological examination revealed that the expression of vascular endothelial cell growth factor and the density of CD31-positive microvessels in metastatic foci were both significantly reduced in TF14016-treated mice. Collectively, CXCR4 could be an attractive target for anti-metastatic and anti-angiogenic therapy in SCLC. |
| Keywords: | TF14016 d-Lys-Pro-Tyr-Arg-Cit-Cys-Arg-NH2 (S-S bridged)" target="_blank">4-Fluorobenzoyl-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-d-Lys-Pro-Tyr-Arg-Cit-Cys-Arg-NH2 (S-S bridged) |
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