首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Ribosome inactivating proteins and apoptosis
Authors:Narayanan Sriram  Surendranath Kalpana  Bora Namrata  Surolia Avadhesha  Karande Anjali A
Institution:Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India.
Abstract:Ribosome inactivating proteins (RIPs) are protein toxins that are of plant or microbial origin that inhibit protein synthesis by inactivating ribosomes. Recent studies suggest that RIPs are also capable of inducing cell death by apoptosis. Though many reports are available on cell death induced by RIPs, the mechanism involved is not well studied. Comparison of pathways of apoptosis and cellular events induced by various RIPs suggests a central role played by mitochondria, probably acting as an integrator of cellular stress and cell death. The purpose of this review is to compare the various apoptotic pathways that may be involved and propose a general pathway in RIP-induced cell death.
Keywords:RIP  ribosome inactivating protein  TNF  tumor necrosis factor  AOP  anti-oxidant protein  MMP  mitochondrial membrane potential (Δψm)  ML  mistletoe lectin  PARP  poly(ADP-ribose) polymerase  ROS  reactive oxygen species  ST  Shiga toxin  PE  Pseudomonas exotoxin  CHX  cycloheximide  PNAG  Polynucleotide N-glycosidase
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号