Defending the end zone: Studying the players involved in protecting chromosome ends |
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Authors: | Suzanne S Chan |
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Institution: | a Department of Genetics, The M.D. Anderson Cancer Center, 1010 Holcombe Blvd., Houston, TX 77030, USA b Department of Hematopathology, The M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA |
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Abstract: | The linear nature of eukaryotic chromosomes leaves natural DNA ends susceptible to triggering DNA damage responses. Telomeres are specialized nucleoprotein structures that comprise the “end zone” of chromosomes. Besides having specialized sequences and structures, there are six resident proteins at telomeres that play prominent roles in protecting chromosome ends. In this review, we discuss this team of proteins, termed shelterin, and how it is involved in regulating DNA damage signaling, repair and replication at telomeres. |
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Keywords: | Telomere Shelterin DNA damage response NHEJ |
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