Role of prostaglandin E2 in peptidoglycan mediated iNOS expression in mouse peritoneal macrophages in vitro |
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Authors: | Yogesh Dahiya |
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Institution: | School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India |
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Abstract: | Many extracellular stimuli, e.g. microbial products, cytokines etc., result in the expression of inducible nitric oxide synthase (iNOS) in macrophages. However, it is not known whether expression of the iNOS gene in response to microbial products is a primary response of macrophages, or is the result of paracrine/autocrine signalling induced by endogenous biomolecules that are synthesised as a result of host cell-microbe interaction. In this paper we demonstrate that iNOS expression in mouse peritoneal macrophages in response to bacterial peptidoglycan (PGN) is a secondary effect requiring autocrine signalling of endogenously produced prostaglandin E2, and that PGN stimulation is mandatory, but not sufficient in itself, for induction of iNOS expression. |
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Keywords: | iNOS inducible nitric oxide synthase COX2 cyclooxygenase 2 PGN peptidoglycan PGE2 prostaglandin E2 |
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