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High-fat diet induced adiposity and insulin resistance in mice lacking the myotonic dystrophy protein kinase |
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| Authors: | Esther Llagostera Meritxell Vicente Perla Kaliman |
| Institution: | a Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain b Diabetes and Obesity Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Hospital Clínic, Universitat de Barcelona, Barcelona, Spain c Medical Psychology Unit, Department of Psychiatry and Forensic Medicine, School of Medicine, Institute of Neurosciences, Autonomous University of Barcelona, E-08193 Bellaterra, Barcelona, Spain |
| Abstract: | Myotonic dystrophy 1 (MD1) is caused by a CTG expansion in the 3′-unstranslated region of the myotonic dystrophy protein kinase (DMPK) gene. MD1 patients frequently present insulin resistance and increased visceral adiposity. We examined whether DMPK deficiency is a genetic risk factor for high-fat diet-induced adiposity and insulin resistance using the DMPK knockout mouse model. We found that high-fat fed DMPK knockout mice had significantly increased body weights, hypertrophic adipocytes and whole-body insulin resistance compared with wild-type mice. This nutrient-genome interaction should be considered by physicians given the cardiometabolic risks and sedentary lifestyle associated with MD1 patients. |
| Keywords: | Myotonic dystrophy 1 DMPK Diet Diabetes Obesity Insulin resistance |
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