首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Sleep and circadian rhythms: key components in the regulation of energy metabolism
Authors:Laposky Aaron D  Bass Joseph  Kohsaka Akira  Turek Fred W
Institution:Northwestern University, Department of Neurobiology and Physiology, 2205 Tech Drive, Hogan 2-160, Evanston, IL 60208-3520, United States. a-laposky@northwestern.edu
Abstract:In this review, we present evidence from human and animal studies to evaluate the hypothesis that sleep and circadian rhythms have direct impacts on energy metabolism, and represent important mechanisms underlying the major health epidemics of obesity and diabetes. The first part of this review will focus on studies that support the idea that sleep loss and obesity are "interacting epidemics." The second part will discuss recent evidence that the circadian clock system plays a fundamental role in energy metabolism at both the behavioral and molecular levels. These lines of research must be seen as in their infancy, but nevertheless, have provided a conceptual and experimental framework that potentially has great importance for understanding metabolic health and disease.
Keywords:Sleep  Circadian rhythms  Circadian clock genes  Obesity  Metabolic syndrome  Sleep deprivation
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号