Tapping the treasure of intracellular oncotargets with immunotherapy |
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Authors: | Cheng William Hong Qi Zeng |
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Institution: | 1. Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA;2. Institute of Molecular and Cell Biology, A∗STAR (Agency for Science, Technology and Research), Republic of Singapore;3. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Republic of Singapore |
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Abstract: | It is commonly believed that antibodies are too large (∼150 kDa) to access the intracellular compartment. Therefore, therapeutic antibodies have been traditionally used to target cell surface receptors or soluble proteins in the circulation, leaving a large intracellular treasure of potential cancer-specific targets untapped. This review offers new perspectives on our recently proposed concept that antibodies can be used to target intracellular tumor antigens for anti-cancer therapy. We propose to vastly expand the repertoire of potential targets for cancer immunotherapy since many excellent cancer targets are inside cells. |
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Keywords: | Cancer Immunotherapy Antibody therapy Vaccination Extracellular receptor Intracellular oncotarget |
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