Tumor suppressor microRNAs: A novel non-coding alliance against cancer |
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| Authors: | Giovanni Blandino Francesco Fazi Sara Donzelli Merav Kedmi Aldema Sas-Chen Paola Muti Sabrina Strano Yosef Yarden |
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| Institution: | 1. Translational Oncogenomics Unit, Italian National Cancer Institute ‘Regina Elena’, Rome, Italy;2. Department of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Rome, Italy;3. Weizmann Institute of Science, Department of Biological Regulation, Rehovot, Israel;4. Department of Oncology, Juravinski Cancer Center-McMaster University Hamilton, Ontario, Canada;5. Molecular Chemoprevention Unit, Italian National Cancer Institute ‘Regina Elena’, Rome, Italy |
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| Abstract: | Tumor initiation and progression are the outcomes of a stepwise accumulation of genetic alterations. Among these, gene amplification and aberrant expression of oncogenic proteins, as well as deletion or inactivation of tumor suppressor genes, represent hallmark steps. Mounting evidence collected over the last few years has identified different populations of non-coding RNAs as major players in tumor suppression in almost all cancer types. Elucidating the diverse molecular mechanisms underlying the roles of non-coding RNAs in tumor progression might provide illuminating insights, potentially able to assist improved diagnosis, better staging and effective treatments of human cancers. Here we focus on several groups of tumor suppressor microRNAs, whose downregulation exerts a profound oncologic impact and might be harnessed for the benefit of cancer patients. |
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| Keywords: | Tumor suppressor microRNAs Cancer |
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