Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats |
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Authors: | Kume Yukio Ikeda Hitoshi Inoue Morihiro Tejima Kazuaki Tomiya Tomoaki Nishikawa Takako Watanabe Naoko Ichikawa Tatsuya Kaneko Makoto Okubo Shigeo Yokota Hiromitsu Omata Masao Fujiwara Kenji Yatomi Yutaka |
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Institution: | Department of Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. |
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Abstract: | ADAMTS13 is gaining attention, because its deficiency causes thrombotic thrombocytopenic purpura. Although its regulatory mechanism is not fully understood, we wondered if hepatic stellate cells (HSCs) play a role, because ADAMTS13 mRNA is exclusively expressed in the liver and primarily in HSCs. Plasma ADAMTS13 activity was markedly reduced in dimethylnitrosamine-treated rats, where HSC apoptosis is an essential event, but not in carbon tetrachloride- or thioacetamide-treated rats without HSC apoptosis. Furthermore, plasma ADAMTS13 activity was also reduced in 70% hepatectomized rats, where HSC loss occurs. These results suggest that HSC may be involved in the regulation of plasma ADAMTS13 activity. |
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Keywords: | ADAMTS13 Hepatic stellate cell Dimethylnitrosamine Hepatectomy |
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