Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion |
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| Authors: | Chen Yan Dabovic Branka Annes Justin P Rifkin Daniel B |
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| Institution: | Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA. |
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| Abstract: | Latent transforming growth factor-beta (TGF-beta) binding protein (LTBP)-1, which is easily secreted, has been shown to enhance the secretion of TGF-beta. Here we show that another member of the LTBP family, LTBP-3, is not secreted by several cell types, but secretion occurs after coexpression with TGF-beta. The secretion of LTBP-3 requires complexing of LTBP-3 with Cys33 of the TGF-beta propeptide. |
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