MicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1 |
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Authors: | Stuart Hunt Adam V Jones Emma E Hinsley Simon A Whawell Daniel W Lambert |
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Institution: | Oral Disease Research Group, School of Clinical Dentistry, University of Sheffield, S10 2TA, UK |
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Abstract: | Alterations in the levels of molecules which interact with the extracellular matrix, such as integrins, are associated with invasion of oral squamous cell carcinomas (OSCC). The molecular mechanisms underlying dysregulation of integrin expression in OSCC, however, remain unclear. Here, we show that microRNA-124, a small non-coding RNA down-regulated in OSCC, is able to downregulate expression of integrin beta-1 (ITGB1) by interacting with its 3′ untranslated region. Over-expression of miR-124 attenuates endogenous ITGB1 expression and reduces the adherence and motility of OSCC cells, suggesting disruption of miR-124-mediated repression of ITGB1 may be a key factor in OSCC progression. |
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Keywords: | Abbreviations: OSCC oral squamous cell carcinoma ITGB1 integrin beta-1 ITGB6 integrin beta-6 3&prime UTR 3&prime untranslated region ECM extracellular matrix MMP matrix metalloproteinase miRNA microRNA |
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