Kir2.3 knock-down decreases IK1 current in neonatal rat cardiomyocytes |
| |
Authors: | He Yusong Pan Qin Li Jun Chen Huaizhi Zhou Qinshu Hong Kui Brugada Ramon Perez Guillermo J Brugada Pedro Chen Yi-Han |
| |
Institution: | Department of Cardiology, Tongji Hospital, Tongji University, Shanghai, China. |
| |
Abstract: | Inward rectifier potassium Kir2.x channels mediate cardiac inward rectifier potassium currents (I(K1)). As a subunit of Kir2.x, the physiological role of Kir2.3 in native cardiomyocytes has not been reported. This study shows that Kir2.3 knock-down remarkably down-regulates Kir2.3 expression (Kir2.3 protein was reduced to 19.91+/-3.24% on the 2nd or 3rd day) and I(K1) current densities (at -120 mV, control vs. knock-down: -5.03+/-0.24 pA/pF, n=5 vs. -1.16+/-0.19 pA/pF, n=7, P<0.001) in neonatal rat cardiomyocytes. The data suggest that Kir2.3 plays a potentially important role in I(K1) currents in neonatal rat cardiomyocytes. |
| |
Keywords: | Inward rectifier channel Kir2 3 K+ channel |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|