The role of insulin-like growth factor I monitoring in growth hormone-treated children |
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Authors: | Park Patricia Cohen Pinchas |
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Institution: | Division of Endocrinology, Department of Pediatrics, Mattel Children's Hospital at UCLA, Los Angeles, CA 90095-1752, USA. |
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Abstract: | Growth hormone (GH) therapy has evolved rapidly over the past decade, and continuing research has established a clear role for therapeutic GH in a wide spectrum of disorders, including idiopathic GH deficiency (childhood- and adult-onset), Turner syndrome, Prader-Willi syndrome, small-for-gestational age children with failure of catch-up growth, AIDS-related catabolism, children with chronic renal failure, and idiopathic short stature. Although GH is used therapeutically in a wide variety of conditions, actual guidelines regarding the logistics of GH dosing continue to evolve, with data emerging regarding efficacy and safety. This review proposes a role for insulin-like growth factor I measurement in optimizing GH dosing. |
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