Neonatal screening for congenital adrenal hyperplasia using 17-hydroxyprogesterone assay in filter paper blood spots |
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| Authors: | A Larsson L Hagenfeldt U von D?beln T Curstedt J Gustafsson E Svensson |
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| Institution: | Department of Bacteriology, National Bacteriological Laboratory, Stockholm, Sweden. |
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| Abstract: | Screening of infants for congenital adrenal hyperplasia (CAH) using filter paper blood samples collected on the 5th day of life was performed with a radioimmunoassay for 17-hydroxyprogesterone without extraction with organic solvents. A total of 153,000 newborns were screened and 12 cases of CAH were detected (1:12,800). With recall levels related to gestational age, the recall rate could be lowered to 0.05%. |
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