| 链霉菌Streptomyces sp.KIB-H1424中的一个新的烷基间苯二酚类化合物 |
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| 引用本文： | 张周鑫,侯冠雄,马亚团,黄建萍,罗剑英,杨静,颜一军,黄胜雄.链霉菌Streptomyces sp.KIB-H1424中的一个新的烷基间苯二酚类化合物[J].天然产物研究与开发,2019(9):1591-1595. |
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| 作者姓名： | 张周鑫 侯冠雄 马亚团 黄建萍 罗剑英 杨静 颜一军 黄胜雄 |
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| 作者单位： | 云南大学化学科学与工程学院;中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室;云南中医学院中药学院 |
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| 基金项目： | 云南省应用基础研究面上项目(2016FB021);国家自然科学基金(81522044) |
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| 摘 要： | 运用色谱学方法对一株来自云南省玉溪市元江县的土壤链霉菌Streptomyces sp.KIB-H1424的次级代谢产物进行分离纯化,得到6个单体化合物。运用NMR、MS及与文献数据对比等手段,确定其为一系列的烷基间苯二酚类似物,其中包括1个新的烷基间苯二酚类化合物Adiposatatin E(1)以及5个已知的烷基间苯二酚类似物Adipostatin A(2)、Adiposatin B(3)、Adipostatin C(4)、Adipostatin D(5)和5-Heptadecyl-1,3-benzenediol(6)。运用滤纸片法测定6个化合物对几种病原细菌和真菌的抑菌活性,发现化合物1~6不具有显著的抑菌活性。
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| 关 键 词： | 链霉菌 次级代谢产物 分离鉴定 烷基间苯二酚 |
A new 5-alkenylresorcinol Adipostatin E from Streptomyces sp.KIB-H1424 |
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| ZHANG Zhou-xin,HOU Guan-xiong,MA Ya-tuan,HUANG Jian-ping,LUO Jian-ying,YANG Jing,YAN Yi-jun,HUANG Sheng-xiong.A new 5-alkenylresorcinol Adipostatin E from Streptomyces sp.KIB-H1424[J].Natural Product Research and Development,2019(9):1591-1595. |
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| Authors: | ZHANG Zhou-xin HOU Guan-xiong MA Ya-tuan HUANG Jian-ping LUO Jian-ying YANG Jing YAN Yi-jun HUANG Sheng-xiong |
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| Institution: | (School of Chemical Science and Technology,Yunnan University,Kunming 650091,China;State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China;College of Pharmaceutical Science,Yunnan University of Traditional Chinese Medicine,Kunming 650500,China) |
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| Abstract: | A new 5-alkenylresorcinol Adipostatin E ( 1) with five known congeners,Adipostatin A (2),Adipostatin B (3),Adipostatin C (4),Adipostatin D (5 ),and 5-Heptadecyl-1,3-benzenediol ( 6 ) were isolated and purified from the culture broth of Streptomyces sp.KIB-H1424,which was isolated from soil sample collected in Yuanjiang county in Yuxi of Yunnan Province,China.The structures of the six isolates were characterized through extensive analysis and compared of NMR and mass spectrometry data with known compounds.The antibacterial and antifungal experiments demonstrated that none of the isolates possesses significant antimicrobial activity against the tested pathogenic bacterium and fungus. |
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| Keywords: | Streptomyces secondary metabolites isolation and identification 5-alkenylresorcinol |
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