抗补体活性多糖

补体系统在宿主免疫中具有重要的作用。近年来,由某些中药中纯化的多糖具有明显的抗补体作用。这些多糖大多数含有阿拉伯糖、半乳糖和半乳糖醛酸,分子量范围6.000到500.000。它们的结构很复杂,多为具聚鼠李半乳糖醛酸结构中心的酸性杂多糖和果胶类多糖。这些多糖的抗补体活性可能和整个大分子的结构有关。一旦发生降解活性就大为下降甚至消失。它们都可以经典的方式激活补体系统。大部分也可以改变的方式激活补体系统。

ANTI-COMPLEMENTARY POLYSACCHARIDES

The complementary system plays an important role in the host defence system. Recent years, some polysaccharides that purified from chinese traditional medicine showed anti-complementary activity. Most of the polysaccharides consisted with arabinose, galactose and galacturonic acid. The range of their molecular weight is from 6,000 to 500,000. Their structures are quite complex and most of them are acidic heteroglycans and pectic polysaccharides which possessed rhamnogalacturonan core. The anti-complementary activity of those polysaccharides seems that related to their whole moieties. Once those moieties were decomposed,their activity would decreased significantly or disappear even. All of the polysaccharides can activate the complement system by the classical pathway,and most of them can activate the complement system by alternative pathway also.