| 红树林植物木果楝细胞毒活性和化学成分研究 |
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| 引用本文： | 戴好富,梅文莉,曾艳波,洪葵,庄令.红树林植物木果楝细胞毒活性和化学成分研究[J].天然产物研究与开发,2007,19(1):74-76. |
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| 作者姓名： | 戴好富 梅文莉 曾艳波 洪葵 庄令 |
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| 作者单位： | 中国热带农业科学院热带生物技术研究所,热带作物生物技术国家重点实验室,海口,571101 |
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| 基金项目： | 中国热带农业科学院科研基金 |
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| 摘 要： | 本研究采用MTT法对红树林植物木果楝(Xylocarpus grantum)正己烷提取物进行细胞毒活性筛选,结果显示对宫颈癌Hela细胞有较强的生长抑制活性。为了确定其中的活性成分,利用GC/MS法对正己烷提取物的化学成分进行分析,共鉴定了17种成分,大部分为有机酸类化合物。其中油酸(Oleic acid,24.89%)、棕榈酸(Palmitic acid,24.82%)和亚油酸(Linoleic acid,16.86%)为主要成分,据文献报道亚油酸具有肺腺癌细胞生长抑制活性。
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| 关 键 词： | 楝科 木果楝 细胞毒活性 化学成分 亚油酸 |
| 文章编号： | 1001-6880（2007）01-0074-03 |
| 收稿时间： | 2005-03-14 |
| 修稿时间： | 2005-04-12 |
Study on Chemical Constituents and Cytotoxic Activity of Mangrove Plant Xylocarpus grantum |
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| DAI Hao-fu,MEI Wen-li,ZENG Yan-bo,HONG Kui,ZHUANG Ling.Study on Chemical Constituents and Cytotoxic Activity of Mangrove Plant Xylocarpus grantum[J].Natural Product Research and Development,2007,19(1):74-76. |
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| Authors: | DAI Hao-fu MEI Wen-li ZENG Yan-bo HONG Kui ZHUANG Ling |
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| Institution: | State Key Laboratory of Tropical Crops Biotechnology,the Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences ,Haikou 571101, China |
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| Abstract: | The hexane extract from a mangrove plant Xylocarpus grantum showed strong growth inhibition effect on Hela cell line by MTT assay.To determine the bioacitve components of hexane extract,17 compounds were identified by GC/MS.Most of the compounds were organic acids.Among them,oleic acid(24.89%),palmitic acid (24.82%)and linoleic acid(16.86%) were major components.It is reported that linoleic acid had growth inhibition effect against lung adenocarcinoma cells. |
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| Keywords: | Meliaceae Xylocarpus grantum cytotoxic activity chemical constituents linoleic acid |
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