兖州卷柏化学成分及体外抗菌活性研究

本文研究兖州卷柏Selaginella involvens Spring.的化学成分及体外抗菌活性.运用反复色谱层析进行纯化分离得到7个化合物,经波谱解析结合理化鉴定确定化合物结构为:正十六烷酸(1),正十八烷酸(2),β-谷甾醇(3),豆甾醇(4),穗花杉双黄酮(5),β-D-glucopyranoside,(3β)-cholest-5-en-3yl(6),β-香树脂醇(7).化合物1～7均首次从该植物中分离得到,6和7首次从该属植物中分离得到.此外研究了化合物5、6和7的体外抗菌活性.化合物5、6和7可能为兖州卷柏抗肺炎病菌的主要物质基础.

Study on the Chemical Constituents of Selaginella involvens Spring and Antibacterial Activity

The chemical constituents of Selaginella involvens Spring were studied on in this paper.Seven compounds were isolated by various chromatographic techniques and the structures were elucidated on the basis of spectral analysis as hexadecanoic acid(1),stearic acid(2),β-sitosterol(3),stigmasterol(4),amentoflavone(5),β-D-glucopyranoside,(3β)-cholest-5-en-3yl(6)and β-amyrin(7).Compounds 1-7 were isolated from this plant for the first time.6 and 7 were reported as constituents of Selaginella for the first time.Meanwhile the antibacterial activities of 5,6 and 7 were studied on 5,6 and 7 showed antibacterial activities.Meanwhile 5,6 and 7 were the main components of antibacterial activities in Selaginella involvens spring.