| 异甾体生物碱类化合物及药理活性研究进展 |
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| 引用本文： | 王安汶,刘玉明.异甾体生物碱类化合物及药理活性研究进展[J].天然产物研究与开发,2022(1). |
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| 作者姓名： | 王安汶 刘玉明 |
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| 作者单位： | 天津理工大学化学化工学院;天津市药物靶向与生物成像重点实验室 |
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| 基金项目： | 国家自然科学基金(31970373);天津市高校创新团队培育项目(TD13-5020)。 |
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| 摘 要： | 异甾体生物碱类结构多变,药理活性多样,主要分布于百合科贝母属和藜芦属植物中。近十五年内共报道了80个新发现的异甾体生物碱类成分,药理活性涉及抗炎、镇痛、降压、平喘、抗血栓、胆碱酯酶抑制、抗病毒和抗肿瘤等作用。本文综述了2006至2020年间该类化合物的植物来源、化学结构及药理活性,并对该类化合物的未来研究探索进行了讨论与展望。
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| 关 键 词： | 异甾体生物碱 化学结构 药理活性 |
Research progress of isosteroidal alkaloids and their pharmacological activities |
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| WANG An-wen,LIU Yu-ming.Research progress of isosteroidal alkaloids and their pharmacological activities[J].Natural Product Research and Development,2022(1). |
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| Authors: | WANG An-wen LIU Yu-ming |
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| Institution: | (School of Chemistry and Chemical Engineering,Tianjin University of Technology;Tianjin Key Laboratory of Drug Targeting and Bioimaging,Tianjin 300384,China) |
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| Abstract: | Isosteroidal alkaloids have variable structures and diverse pharmacological activities,and are mainly distributed in the genera Fritillaria and Veratrum in Liliaceae.In the past 15 years,relevant literatures have reported 80 novel isosteroidal alkaloids.Their pharmacological activities include anti-inflammatory,analgesic,antihypertensive,antiasthmatic,antithrombotic,cholinesterase inhibition,antiviral and antitumor effects.This paper summarized botanical sources,chemical structures and bioactivities of isosteroidal alkaloids from 2006 to 2020.The future research and exploration of isosteroidal alkaloids were discussed and prospected. |
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| Keywords: | isosteroidal alkaloids chemical structure pharmacological activity |
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