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| 一株南海红树林底泥抗真菌放线菌(No.H74-18)的化学成分研究 | |
| 引用本文： | 许琳雅,王成,徐文,沈会芳,周光雄,林壁润.一株南海红树林底泥抗真菌放线菌(No.H74-18)的化学成分研究[J].天然产物研究与开发,2010,22(2). |
| 作者姓名： | 许琳雅 王成 徐文 沈会芳 周光雄 林壁润 |
| 作者单位： | 1. 暨南大学药学院中药及天然药物研究所,广州,510632 2. 广东省农业科学院植物保护研究所广东省植物保护新技术重点实验室,广州,510110 3. 暨南大学药学院中药及天然药物研究所,广州,510632;广州中医药大学第二临床医学院中药制剂实验室,广州,510120 |
| 基金项目： | 国家自然科学基金委基金 |
| 摘 要： | 对我国南海红树林底泥中分离的一株放线菌(No.H74-18)的发酵菌丝体采用95%乙醇提取,并对具有抗真菌活性的乙酸乙酯部位进行研究,通过硅胶开放柱色谱分离得到了一个结晶样品。通过制备型反相高效液相色谱分离,从此结晶样品中分离纯化出3个化合物,经NMR、MS等光谱学方法分别鉴定为抗霉素A1(1)、抗霉素A2a(2)、抗霉素A3(3),这些化合物都是抗霉素类化合物。采用LC-MS联用技术分析了此结晶样品中存在的抗霉素类的可能组份。 |
| 关 键 词： | 红树林 放线菌 抗霉素 LC-MS联用技术 |
Chemical Constituents of Antifungal Actinomycete Strain (No.H74-18) from the Mangrove Zone of South China Sea |
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| XU Lin-ya,WANG Cheng,XU Wen,SHEN Hui-fang,ZHOU Guang-xiong,LIN Bi-run.Chemical Constituents of Antifungal Actinomycete Strain (No.H74-18) from the Mangrove Zone of South China Sea[J].Natural Product Research and Development,2010,22(2). | |
| Authors: | XU Lin-ya WANG Cheng XU Wen SHEN Hui-fang ZHOU Guang-xiong LIN Bi-run |
| Institution: | XU Lin-ya1,WANG Cheng2,XU Wen1,3,SHEN Hui-fang2,ZHOU Guang-xiong1,LIN Bi-run21Institute of Traditional Chinese Medicine , Natural Products,College of Pharmacy Jinan University,Guangzhou 510632,China,2Key Labotery of New technique for Plant protection in Guangdong,Institute of Plant Protection,Guangdong Academy of Agricultural Sciences,Guangzhou 510110,3The Second Clinical Medicine Collaege,Guangzhou University of TCM,Guangzhou 510120 |
| Abstract: | The cultured filaments of an actinomycete strain (NO.H74-18),which was purified from the bottom earth of mangrove zone in south China sea,was extracted by 95% ethanol.Research on the antifungal ethyl acetate fraction from the alcoholic extract led to obtain a crystalline sample by silica gel column chromatography.Three compounds were isolated from this crystal sample by preparative reverse phase HPLC,and were identified as Antimycin A1(1),antimycin A2a(2),antimycin A3(3) by spectroscopic methods including N... |
| Keywords: | Actinomycete Antimycin LC-MS technology |
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