| 栀子兰色素可能为栀子粉末外用抗炎消肿时的活性物质 |
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| 引用本文： | 赵维民,季新泉,叶庆华,秦国伟,徐任生,朱兴族.栀子兰色素可能为栀子粉末外用抗炎消肿时的活性物质[J].天然产物研究与开发,2000,12(4):41-44. |
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| 作者姓名： | 赵维民 季新泉 叶庆华 秦国伟 徐任生 朱兴族 |
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| 作者单位： | 中国科学院上海药物研究所,上海,200031 |
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| 摘 要： | 传统中药山栀子中的环烯醚萜成分及尼平（ｇｅｎｉｐｉｎ）与甘氨酸反应可形成兰色素，初步药理实验显示，该兰色色素对小鼠具有抗炎和镇痛作用，推测栀子兰色素可能为民间将栀子粉末外用抗炎消肿时的活性物质。
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| 关 键 词： | 山栀子 天然兰色素 中药 药理 抗炎活性 |
| 修稿时间： | 1999年2月5日 |
GARDENIA BLUE PIGMENTS MAY BE ESSENTIAL TO ANTI-INFLAMMATORY ROLE OF THE FRUITS OF GARDENIA JASMONOIDES ELLIS |
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| Zhao Weimin,Ji Xinquan,Ye Qinghua,Qin Guowei,Xu Rensheng,Zhu Xingzu.GARDENIA BLUE PIGMENTS MAY BE ESSENTIAL TO ANTI-INFLAMMATORY ROLE OF THE FRUITS OF GARDENIA JASMONOIDES ELLIS[J].Natural Product Research and Development,2000,12(4):41-44. |
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| Authors: | Zhao Weimin Ji Xinquan Ye Qinghua Qin Guowei Xu Rensheng Zhu Xingzu |
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| Abstract: | To study relationship between Gardenia blue pigment and amti inflammatory effect of fruits of Gardenia jasminoides .Methods:Blue pigments were derived from glycine and iridoid compounds genipin and mussaenoside.Anti inflammatory and analgesic effects of the blue pigments were evaluated in mice at dosages of 25 mg/kg and 30 mg/kg,respectively.Results:Blue pigment 1 exhibited anti inflammatory and analgesic effects,blue pigment 2 exhibited anti inflammatory effect,and the effect was much stronger than that of mussaenoside.Conclusion:These blue pigments may contribute to the therapeutic role of fruits of Gardenia jasminoides when the powder of which were used externally to subside swelling in folk medicine. |
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| Keywords: | Gardenia jasminoides iridoid natural blue pigment anti inflammatory activity analgesic activity swelling subsiding |
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