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| 竹叶提取物对心肌缺血再灌注损伤的保护作用 | |
| 引用本文： | 付晓春,李少鹏,王敏伟,王怀良.竹叶提取物对心肌缺血再灌注损伤的保护作用[J].天然产物研究与开发,2006,18(2):214-218. |
| 作者姓名： | 付晓春 李少鹏 王敏伟 王怀良 |
| 作者单位： | 1. 广东化工制药职业技术学院,广东省中药研究所,广州,510520 2. 中国医科大学神经外科,沈阳,110016 3. 沈阳药科大学药理教研室,沈阳,110016 4. 中国医科大学临床药理教研室,沈阳,110016 |
| 摘 要： | 本文通过两种不同的模型来探讨竹叶提取物对心肌缺血再灌注(缺氧/复氧)损伤的保护作用。在体内模型中不同剂量的竹叶提取物均提高了模型组室内压最大上升和下降速率,降低了左室末期舒张期压力,提高了心输出量。同时降低了模型组肌酸磷酸激酶及乳酸脱氢酶的活性,减少了丙二醛的含量,增加了超氧化物歧化酶的活性,通过电压依赖性钙通道及受体依赖性钙通道降低了钙的含量。说明竹叶提取物对心肌缺血再灌注(缺氧复氧)损伤具有保护作用,其作用是通过电压依赖性钙通道及受体依赖性钙通道降低了钙的含量而对心肌缺血再灌注(缺氧复氧)损伤产生保护作用。 |
| 关 键 词： | 竹叶提取物 缺血再灌注 缺氧复氧 自由基 心肌 |
| 文章编号： | 1001-6880（2006）02-0214-5 |
| 收稿时间： | 2005-09-30 |
| 修稿时间： | 2005-12-19 |
Protective Effects of Bamboo Leaves Extract on Ischemia and Reperfusion of Myocardium |
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| FU Xiao-chun,LI Shao-peng,WANG Min-wei,WANG Huai-liang.Protective Effects of Bamboo Leaves Extract on Ischemia and Reperfusion of Myocardium[J].Natural Product Research and Development,2006,18(2):214-218. | |
| Authors: | FU Xiao-chun LI Shao-peng WANG Min-wei WANG Huai-liang |
| Institution: | 1. Guangdong Professional Technique College of Chemical Industry Pharmacy, Chinese Herb Medicine Institute of Guangdong Province, Guangzhou 510520, China;2. Department of Brain Neurosurgery, China Medical University, Shenyang 110016,China;3. Department of Pharmacology ,Shenyang Pharmaceutical University Shenyang 110016, China;4. Department of Clinical Pharmacology, China Medical University , Shenyang 110016, China |
| Abstract: | This research aims to investigate the protective effects of bamboo leaves extract(BLE)on myocardial tissue during ischemia(hypoxia)and reperfusion(reoxygenation)(I/R,H/R)in two different models:i.e.dog heart and rat cardiomyocytes.The results showed that BLE improved cardiac function:The maximal rise or decline rate of intraventricular pressure( /-dp/dt_(max))was elevated,left ventricular end dilation pressure(LVEDP)was lowered,and the cardiac output(CO)was increased.The release of creatine kinase(CK)and lactate dehydrogenase(LDH)into serum and the level of malondialdehyde(MDA)in myocardial tissues were decreased and infarct size was also reduced;BLE decreased LDH release and the content of MDA,increased superoxide dismutase(SOD)activity and reduced the intracellular calcium concentration during H/R;KCl(60 mmol/L)and NE(30 mol/L)-inducedCa~(2 )]_i mobilizations were inhibited by BLE,similar to the effect of Xiangdan.These findings suggest that BLE protects the heart injured by I/R in vivo and H/R in vitro,and it is attributed to its antiperoxdative effect and the antagonistic effects onCa~(2 )]_i increase via voltage-dependent Ca~(2 )channel and receptor-operated Ca~(2 ) channel. |
| Keywords: | bamboo leaves extract ischemia/reperfusion hypoxia/reoxygenation free radicals myocardium |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |