| 柴达木盆地唐古特白刺籽油保护肝损伤作用研究 |
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| 引用本文： | 索有瑞,高航,王洪伦.柴达木盆地唐古特白刺籽油保护肝损伤作用研究[J].天然产物研究与开发,2005,17(5):573-576. |
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| 作者姓名： | 索有瑞 高航 王洪伦 |
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| 作者单位： | [1]中国科学院西北高原生物研究所,西宁810001 [2]中国科学院广州地球化学研究所,广州510640 [3]中国科学院研究生院,北京100039 |
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| 基金项目： | 中国科学院＂西部之光＂人才培养计划 |
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| 摘 要： | 对柴达木盆地唐古特白刺种籽油保护化学性肝损伤作用进行了研究.将小鼠按体重随机分为白刺籽油高、中、低剂量组,另设空白对照组和联苯双酯、藏茵陈阳性对照组.小鼠连续灌胃给药15 d后,用CCl4进行肝损伤,测定小鼠血清谷丙转氨酶（ALT）、谷草转氨酶（AST）;肝脏过氧化脂质（LPO）降解产物丙二醛（MDA）和谷胱甘肽过氧化物酶（GSH-Px）的含量.结果显示,白刺籽油对血清ALT、AST具有显著的抑制作用,显著拮抗肝脏MDA的升高,显著提高肝脏GSH-Px含量.表明白刺籽油具有明显的保护化学性肝损伤的保健作用.
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| 关 键 词： | 唐古特白刺 种籽油 化学性肝损伤 保护作用 |
| 收稿时间： | 2005-01-17 |
| 修稿时间： | 2005-02-22 |
The Protective Effect of Nitraria tangutorum Bobr. Seed Oil from Qaidam Basin on the Liver Injury of Mice |
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| SUO You-rui, GAO Hang,WANG Hong-lun.The Protective Effect of Nitraria tangutorum Bobr. Seed Oil from Qaidam Basin on the Liver Injury of Mice[J].Natural Product Research and Development,2005,17(5):573-576. |
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| Authors: | SUO You-rui GAO Hang WANG Hong-lun |
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| Institution: | 1. Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001, China; 2. Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China; 3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China |
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| Abstract: | The protective effect of seed oil of Nitraria tangutorum Bobr. from Qinghai Qaidam Basin. On the liver injury by chemical reagent was studied in this paper. The mice were randomly divided into three experimental groups according to their weight, the normal control group, two comparison groups of Swertia mussotii and diphenyl bibenzoate. After rats were feed seed oil for 15 days,their liver were injured by CCl4.The content of ALT,AST in serum and the content of MDA, GSH-Px in hver were measured.The result showed that the seed oil could obviously control the content of ALT,AST in serum,prevent the rise of MDA in liver and enhance the content of GSH-Px in liver.The result indicated that the seed oil of Nitraria tangutorum Bobr. has significant protective effect on the mice. |
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| Keywords: | Nitraria tangutorum Bobr Nitraria seed oil liver injury induced by chemical reagent protective effect |
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