牛心朴子须根的化学成分研究

从采自宁夏的萝摩科鹅绒藤属植物牛心朴子 (CynanchumkomaroviiAl.Iljinski.)须根的乙醇提取物中分离鉴定了十个非C2 1 甾体类化合物 :β D 呋喃果糖基 (2→ 1) α D 6 O 芥子酰基 ] 吡喃葡萄糖甙 (1) ,β D (3 O 芥子酰基 ) 呋喃果糖基 (2→ 1) α D 6 O 芥子酰基 ] 吡喃葡萄糖甙 (2 ) ,6 O β D 吡喃葡萄糖基 (1→ 6 ) β D 吡喃葡萄糖基 1,2 双氧 (4 羟基 3,5 二甲氧基肉桂酰 ) (3) ,7 脱甲氧基娃儿藤碱 (4) ,9 羟基 芳樟醇 3 O β D 吡喃木糖基 (1→ 6 ) β D 吡喃葡萄糖甙 (5 ) ,(2E ,6R) 2 ,6 二甲基 2 ,7 辛二烯 1,6 二醇 (6 ) ,(+) 丁香素 ](7) ,4′ O demethylepiyangambin(8) ,4′ 羟基 2′ 甲氧基苯乙酮 (9) ,(2S ,3S ,4R ,12E) N 2′ (R) 羟基二十二碳烷基 ] 1,3,4 三羟基 2 酰胺 二十碳烷基 12 烯 (10 )。除化合物 4和 9外 ,其余化合物均为首次从该植物中分离得到。

THE CHEMICAL CONSTITUENTS OF THE ROOTS OF CYNANCHUM KOMAROVII

Ten known compounds were isolated from the ethanolic extract of the roots of Cynanchum ko-marovii Al. Iljinski. (Asclepiadaceae)collected in Ningxia Hui Autonomous District. Their structures were de-termined by spectroscopic analysis to be β-D- fructofuranosyl- ( 2→1 )-α-D- 6- O- sinapoyl ]-glucopyranoside( 1 ),β-D- ( 3- O-sinapoyl ) -fructofuranosyl- ( 2 → 1 )-α-D- 6- O-sinapoyl ] -glucopyranoside ( 2 ), 6- O-β-D-glucopyra-nosyl-( 1 → 6 )-β-D-glucopyranosyl-1, 2-bis-O-( 4-hydroxy-3, 5-dimethoxycinnamoyl ) ( 3 ), 7-demethoxyty-lophorine ( 4 ), 9- hydroxylinalool-3-O-β-D-xylopyranosyl- ( 1 → 6 )-β-D-glucopyranoside ( 5 ), ( 2E, 6R )-2, 6-dimethyl-2,7-octadiene- 1,6-diol(6), ( + )-syringaresinol ] ( 7 ), 4'- O-demethylepiyangambin ( 8 ), 4'-hydroxy-2'-methoxyl-acetophenone( 9 ), ( 2S, 3S, 4R, 12E )-N- 2'-( R )-hydroxydocosanoate ]-1,3, 4-trihydroxy-2-amino-eicosanoate-12-ene(10). Except for compounds 4 and 9,, the other eight compounds were first reportedfrom this plant.