| Streptomyces pulveraceus突变株中福司曲星类似物的分离鉴定及其生物合成途经初探(英文) |
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| 引用本文： | 孔日祥,马春燕,唐莉.Streptomyces pulveraceus突变株中福司曲星类似物的分离鉴定及其生物合成途经初探(英文)[J].天然产物研究与开发,2013,25(7):882-888. |
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| 作者姓名： | 孔日祥 马春燕 唐莉 |
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| 作者单位： | 大连理工大学分子药物研究中心,大连,116024 |
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| 基金项目： | financially supported by Na-tional Natural Sciecnce Funds for Distinguished Young Scholar30688003 to L.T. |
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| 摘 要： | 福司曲星是一种从Streptomyces pulveraceus分离得到的磷酸酯类、聚酮类抗生素。本文从其突变株(ΔfosJ)分离得到一系列新的福司曲星结构类似物(10～14)。结合各种波谱方法,我们对其结构进行鉴定。由于这些化合物的结构特殊性,初步推断这些化合物可能来自于异常的PKS组合生物合成。
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| 关 键 词： | 福司曲星类似物 聚酮合酶 结构鉴定 |
Isolation and Characterization of a Serial of Novel Fostriecin Analogues from FosJ-Deletion Mutant of Streptomyces pulveraceus Suggesting a Novel Polyketide Biosynthesis Insight |
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| KONG Ri-xiang
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MA Chun-yan
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TANG Li.Isolation and Characterization of a Serial of Novel Fostriecin Analogues from FosJ-Deletion Mutant of Streptomyces pulveraceus Suggesting a Novel Polyketide Biosynthesis Insight[J].Natural Product Research and Development,2013,25(7):882-888. |
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| Authors: | KONG Ri-xiang MA Chun-yan TANG Li |
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| Institution: | * Research Center for Molecular Medicine,Dalian University of Technology,Dalian 116024,China |
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| Abstract: | |
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| Keywords: | fostriecin analogue polyketide synthase structure characterization |
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