| 石参总黄酮对一氧化氮致大鼠胰岛细胞损伤的保护作用 |
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| 引用本文： | 吴伟斌,庞建新,曹莹,谢宝平,丘玉昌.石参总黄酮对一氧化氮致大鼠胰岛细胞损伤的保护作用[J].天然产物研究与开发,2013,25(6):759-761,791. |
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| 作者姓名： | 吴伟斌 庞建新 曹莹 谢宝平 丘玉昌 |
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| 作者单位： | 南方医科大学药学院新药评价中心,广州,510515 |
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| 摘 要： | 采用硝普钠为NO供体,造成大鼠胰岛β细胞RIN-m的损伤,通过检测细胞活力、细胞内丙二醛(MAD)含量、总谷胱甘肽(GSH)含量和总超氧化物歧化酶(SOD)活性,探讨石参总黄酮的保护作用和机制。结果显示,石参总黄酮能明显提高损伤细胞的活力,降低细胞内MDA的含量、提高总GSH含量和SOD活力,表明石参总黄酮对NO所致RIN-m细胞的损伤具有保护作用,其机制可能与提高细胞内GSH含量与SOD活力有关。
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| 关 键 词： | 石参 黄酮 胰岛细胞 一氧化氮 |
Protective Effect of Total Flavonoids from Urariacrinita Root against Injury of Rat Pancreatic Islet Cells Caused by Nitric Oxide |
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| WU Wei-bin
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PANG Jian-xin
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CAO Ying
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XIE Bao-ping
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QIU Yu-chang.Protective Effect of Total Flavonoids from Urariacrinita Root against Injury of Rat Pancreatic Islet Cells Caused by Nitric Oxide[J].Natural Product Research and Development,2013,25(6):759-761,791. |
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| Authors: | WU Wei-bin PANG Jian-xin CAO Ying XIE Bao-ping QIU Yu-chang |
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| Institution: | * Center of Drug Evaluation and Research,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou510515,China |
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| Abstract: | |
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| Keywords: | Urariacrinita flavonoids isletcells nitric oxide |
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