金耳菌丝体多糖对实验性2型糖尿病大鼠的降血糖作用研究

本文研究了金耳菌丝体多糖(TMP)对实验性2型糖尿病大鼠血糖、血脂、胰岛素敏感性和抗氧化能力的影响。采用烟酰胺,链脲佐菌素和高脂饲料诱导2型糖尿病大鼠模型,以50和100mg/(kg.d)剂量的TMP连续灌胃48d,监测血糖,测定血清胰岛素、体重、脂代谢及抗氧化系统部分相关指标,并进行口服糖耐量实验。结果显示,TMP可明显降低2型糖尿病大鼠的血清葡萄糖、总胆固醇、甘油三酯和丙二醛水平,并极显著提高受试模型鼠的胰岛素敏感指数,血清超氧化物歧化酶活性和肝脏过氧化氢酶活性。此外,TMP能显著降低糖耐量实验中糖负荷后120min时糖尿病大鼠的血糖含量。上述结果表明TMP可有效降低实验性2型糖尿病大鼠的血糖水平,纠正脂代谢紊乱,改善胰岛素抵抗,增强抗氧化能力。

Hypoglycemic Activity of Polysaccharides Extracted from Tremella aurantialba Mycelia in Experimental Type 2 Diabetic Rats

The present study was designed to evaluate the effects of crude polysaecharides extracted from Tremella aurantialba mycelia (TMP) on serum glucose, insulin sensitivity,lipid profiles and antioxidant parameters in nicotinamide and streptozotocin (STZ) -induced type 2-like diabetic rats.Type 2-like diabetes in rat was induced by nicotinamide, STZ and high fat diet.50 and 100 mg/(kg·d) TMP were fed by intragastric administration to diabetic rats once a day lasting for 48 days.In this study,we focused on measuring the change of serum glucose,insulin,lipid profiles,antioxidant pa-rameters and body weight to evaluate anti-diabetic effect of 'IMP.Moreover,effect of TMP on oral glucose tolerance test (OGTT) was been investigated.Results showed that administration of TMP significantly lowered the fasting serum glu-ease,total cholesterol (TC) ,triglycerides (TG) and malondialdehyde (MDA) levels in type 2-like diabetic rats.Mean-while,TMP also markedly increased the insulin sensitivity index (ISI) and activities of serum superoxide dismutase (SOD) and hepatic eatalase (CAT).In addition, TMP supplement significantly attenuated the elevated blood glucose levels of diabetic rats after 120 min of glucose loading in oral glucose tolerance test.These findings suggested that TMP might have hypoglycemic,hypolipidemic and antioxidant effects in nicotinamide-STZ induced type 2-like diabetic rats.Furthermore, TMP might improve insulin resistance in diabetic rats.