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| 卷柏化学成分及细胞毒活性研究(英文) | |
| 引用本文： | 曹园,吴永平,温晓舟,翁燕,王强.卷柏化学成分及细胞毒活性研究(英文)[J].天然产物研究与开发,2012,24(2):150-154. |
| 作者姓名： | 曹园 吴永平 温晓舟 翁燕 王强 |
| 作者单位： | 1. 江苏省中医院中药制剂实验室,江苏省中医院肿瘤临床研究中心,南京210036 2. 江苏省药物研究所 3. 中国药科大学中药分析教研室,南京,210009 |
| 摘 要： | 从卷柏(Selaginella tamariscina(Beauv.)Spring)中分离得到10个化合物,运用波谱手段分别鉴定为se-laginellin(1)、selaginellin A(2)、selaginellin B(3)、穗花杉双黄酮(4)、sequoiaflavone(5)、去甲银杏双黄酮(6)、银杏双黄酮(7)、异银杏双黄酮(8)、扁柏双黄酮(9)、异柳杉双黄酮(10)。其中化合物1、5和8为首次从该植物中分离得到。化合物1,4,7,8和9显示出选择性的细胞毒活性。 |
| 关 键 词： | 卷柏 化学成分 selaginellins 双黄酮 细胞毒活性 |
Cytotoxic Constituents from Selaginella tamariscina |
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| CAO Yuan , WU Yong-ping , WEN Xiao-zhou , WENG Yan , WANG Qiang.Cytotoxic Constituents from Selaginella tamariscina[J].Natural Product Research and Development,2012,24(2):150-154. | |
| Authors: | CAO Yuan WU Yong-ping WEN Xiao-zhou WENG Yan WANG Qiang |
| Institution: | 1Laboratory of Chinese Materia Medica Preparation,Center for Clinical Research in Oncology Speciality,Jiangsu Provincial Hospital of Traditional Chinese Medicine,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine; 2Jiangsu Provincial Institute of Materia Medica,Nanjing 210009,China;3Department of Chinese Materia Medica Analysis,China Pharmaceutical University,Nanjing 210009,China |
| Abstract: | Three selaginellins and seven biflavones were isolated from the whole plant of Selaginella tamariscina.Their structures were identified as selaginellin(1),selaginellin A(2),selaginellin B(3),amentoflavone(4),sequoiaflavone(5), bilobetin(6),ginkgetin(7),isoginkgetin(8),hinokiflavone(9),and isocryptomerin(10).Among them,compounds 1,5,and 8 were isolated from this plant for the first time.Additionally,selected compounds were evaluated for their cytotoxic activity against tested human cell lines,and compounds 1,4,7,8 and 9 showed selective cytotoxic activity. |
| Keywords: | Selaginella tamariscina chemical constituents selaginellins biflavones cytotoxic activity |
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