| 海洋真菌Rhizopus sp.2-PDA-61化学成分的研究(英文) |
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| 引用本文： | 王发左,朱天骄,张敏,林爱群,顾谦群.海洋真菌Rhizopus sp.2-PDA-61化学成分的研究(英文)[J].天然产物研究与开发,2011,23(2):199-201,266. |
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| 作者姓名： | 王发左 朱天骄 张敏 林爱群 顾谦群 |
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| 作者单位： | 1. 中国科学院南海海洋研究所,中国科学院海洋生物资源可持续利用重点实验室,中国科学院海洋微生物研究中心,广东省海洋药物重点实验室,广州,510301;中国海洋大学医药学院,教育部海洋药物重点实验室,青岛,266003
2. 中国海洋大学医药学院,教育部海洋药物重点实验室,青岛,266003 |
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| 基金项目： | This work was financially supported by the National Natural Science Foundation of China(40906076);the Shandong Provincial Natural Science Fund(ZR2009CZ016) |
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| 摘 要： | 从海洋真菌根霉2-PDA-61中共发现6个已知化合物,其中包括2个细胞毒活性的环五肽(1和2)和4个苯的衍生物(3~6)。通过波谱学数据分析和与已知化合物数据比较,这些化合物分别被鉴定为malformin C(1)、malformin A1(2)、2,5-二羟基苯乙酸甲酯(3)、对羟基苯乙醇(4)、对甲基苯乙醇(5)和对苯二甲醚(6)。化合物1和2对P388细胞系表现出中等强度的细胞毒活性,IC50值分别为1.8μM和4.2μM。
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| 关 键 词： | 根霉 海洋真菌 malformins 苯的衍生物 |
Chemical Constituents from the Marine-derived Fungus Rhizopus sp.2-PDA-61 |
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| WANG Fa-zuo,ZHU Tian-jiao,ZHANG Min,LIN Ai-qun,GU Qian-qun.Chemical Constituents from the Marine-derived Fungus Rhizopus sp.2-PDA-61[J].Natural Product Research and Development,2011,23(2):199-201,266. |
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| Authors: | WANG Fa-zuo ZHU Tian-jiao ZHANG Min LIN Ai-qun GU Qian-qun |
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| Institution: | 1 Key Laboratory of Marine Bio-resources Sustainable Utilization,Research Center for Marine Microbes,Guangdong Key Laboratory of Marine Materia Medica,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China;2 Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China. |
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| Abstract: | Two cytotoxic cyclicpentapeptides(1 and 2)and four benzene derivatives(3-6)have been isolated from the marine-derived fungus Rhizopus sp.2-PDA-61.By spectral analysis and comparison the data with those of known compounds,they were identified as malformin C(1),malformin A1(2),2,5-dihydroxyphenylacetic acid methyl ester(3),P-hydroxy phenylethanol(4),p-methyl phenylethanol(5),and P-dimethoxybenzene(6),respectively.Moreover,compounds 1 and 2 displayed moderate cytotoxicities to P388 cell lines,and the IC50 values of them were 1.8 μM and 4.2 μM. |
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| Keywords: | molformins |
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