| 黄芩素对3T3-L1小鼠前脂肪细胞分化及对脂肪酸合成酶活性的影响 |
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| 引用本文： | 成俊英,张晓岚,杨扬,申晓云,张崇本.黄芩素对3T3-L1小鼠前脂肪细胞分化及对脂肪酸合成酶活性的影响[J].天然产物研究与开发,2004,16(1):7-9. |
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| 作者姓名： | 成俊英 张晓岚 杨扬 申晓云 张崇本 |
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| 作者单位： | 北京大学生命科学学院,北京,100871 |
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| 摘 要： | 目的 研究黄芩素对3T3-L1小鼠前脂肪细胞分化及对脂肪酸合成酶活性的影响。方法 油红O染色法测定细胞分化速度；分光光度法测定脂肪酸合成酶活性。结果 黄芩素对3T3-L1小鼠前脂肪细胞向脂肪细胞分化以及对脂肪酸合成酶活性有抑制作用。结论 黄芩素通过阻断脂肪合成而抑制小鼠前脂肪细胞分化；黄芩素具有开发成减肥药物的潜力。
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| 关 键 词： | 黄芩素 小鼠 前脂肪细胞 分化 脂肪酸 合成 酶活性 减肥药物 |
EFFECTS OF BAICALEIN ON DIFFERENTIATION OF 3T3-L1 PREADIPOCYTES INTO ADIPOCYTES AND ON FATTY ACID SYNTHASE ACTIVITY |
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| Abstract.EFFECTS OF BAICALEIN ON DIFFERENTIATION OF 3T3-L1 PREADIPOCYTES INTO ADIPOCYTES AND ON FATTY ACID SYNTHASE ACTIVITY[J].Natural Product Research and Development,2004,16(1):7-9. |
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| Authors: | Abstract |
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| Abstract: | Objective To study the effects of baicalein on differentiation of 3T3-L1 murine preadipocytes into adipocytes and on the activities of fatty acid synthase (FAS). Methods Cell differentiation was determined by Oil Red O staining; FAS activity was determined by spectrophotometry. Results Baicalein has inhibition effects on the differentiation of 3T3-L1 preadipocytes into adipocytes and on FAS activities.Conclusion Baicalein attenuates the differentiation of mouse preadipocytes into adipocytes via blocking lipid synthesis and has the potential to be an anti-obesity drug. |
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| Keywords: | baicalein cell differentiation fatty acid synthase obesity |
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