菟丝子三种提取工艺对心血管活性的影响

目的 观察菟丝子不同提取工艺对实验犬血流动力学药效学的影响。方法 16只成年杂种犬随机分成四组，给药组剂量为20mg／kg静脉注射。结果 经初步筛选实验结果表明，三个不同提取工艺样品均能增加心肌冠脉血流量，但3个样品对心肌耗氧量具有不同的影响，其中3号制剂心肌耗氧量降低；而1、2号制剂则增加心肌耗氧量。结论 3个样品各有特点，综合效应3号最佳。

THE EFFECT OF THREE EXTRACTION TECHNIQUE OF CHINESE DODDER SEED ON CARDIOVASCULAR ACTIVITY

Aim: To observe the effect of different extraction techniques of Chinese dodder seed (Cuscuta chinensis Lam.) on pharmacodynamics Method: 16 matured male hybrid dogs were divided into 4 groups randomly, and each medication group was given injection of vein for 1min with different extractions at the dose of 20 mg/kg and 1 ml/kg. Results: The results of the preliminary screening experiment showed that three samples all can significantly increased coronary blood flow, but they had different effect on myocardial oxygen consumption( MOC), in which sample 3 could reduced MOC significantly, but Sample 1 and 2 increased MOC. Conclusion: These 3 samples had their own characteristics, furthermore, sample 3 had the optimum comprehensive effects.