| 两面针化学成分、药理活性及抗肿瘤机制研究进展 |
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| 引用本文： | 刘延成,程风杰,蒙衍强,陈振锋,梁宏.两面针化学成分、药理活性及抗肿瘤机制研究进展[J].天然产物研究与开发,2012,24(4):550-555. |
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| 作者姓名： | 刘延成 程风杰 蒙衍强 陈振锋 梁宏 |
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| 作者单位： | 1. 广西师范大学化学化工学院,药用资源化学与药物分子工程教育部重点实验室,桂林541004
2. 柳州两面针股份有限公司,柳州,545006 |
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| 基金项目： | 国家自然科学基金，广西自然科学基金，广西教育厅基金，教育部重点实验室基金资助项目 |
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| 摘 要： | 本文主要结合近几年的国内外研究报道,综述了中国传统中草药-两面针的化学成分、药理活性及临床疗效等方面的研究进展;并结合作者所在课题组的研究成果,重点介绍了两面针生物碱及其金属配合物的抗肿瘤活性研究。
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| 关 键 词： | 两面针 生物碱 氯化两面针碱 抗肿瘤机制 金属配合物 |
Research Progresses on the Chemical Components, Pharmacological Activity, and Antitumoral Mechanism of Zanthoxylum nitidum |
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| LIU Yan-cheng
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CHENG Feng-jie
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MENG Yan-qiang
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CHEN Zhen-feng
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LIANG Hong.Research Progresses on the Chemical Components, Pharmacological Activity, and Antitumoral Mechanism of Zanthoxylum nitidum[J].Natural Product Research and Development,2012,24(4):550-555. |
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| Authors: | LIU Yan-cheng CHENG Feng-jie MENG Yan-qiang CHEN Zhen-feng LIANG Hong |
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| Institution: | 1School of Chemistry and Chemical Engineering,Key Laboratory for the Chemistry and Molecular Engineering of Medicinal, Resources(Ministry of Education China),Guangxi Normal University,Guilin 541004,China; 2Liuzhou Liangmianzhen Co.Ltd.,Liuzhou,545006,China |
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| Abstract: | In this paper,the research progress on the chemical components,pharmacological activity and clinical effects of Zanthoxylum nitidum(TCM) mainly in the recent ten years was reviewed.As emphasis,several kinds of alkaloids,the main components of Z.nitidum,such as nitidine chloride,liriodenine as well as its metal complexes with antitumour activity,were summarized. |
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| Keywords: | Zanthoxylum nitidum alkaloids nitidine chloride antitumor activity metal complex |
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