南海柳珊瑚鳞海底柏化学成分的研究

本文对南海柳珊瑚鳞海底柏Melitodes squarnata Nutting进行了化学成分的研究.通过用工业乙醇:二氯甲烷(2∶1)进行了提取,采用硅胶柱色谱、Sephadex LH-20凝胶色谱、高效液相半制备色谱和薄层制备等方法对鳞海底柏的化学成分进行了分离,并利用波谱分析技术和文献对照鉴定其结构.从鳞海底柏中分离得到了17个化合物,分别鉴定为:malonganenone E(1),malonganenone D(2),nuttingin A(3),腺嘌呤核苷(4),1,3,7-三甲基黄嘌呤(5),2'-脱氧胸腺嘧啶核苷(6),3-甲基-6-次黄嘌呤(7),2'-脱氧尿苷(8),(22E,24R)-ergosta-8 (14),22-dien-3β,5α,6β,7α-tetrol(9),(22E)-胆甾-5,22-二烯-3β-醇(10),胆甾醇(11),(2S,3S,4R)-N-hexadecanoyl-2-amino-1,3,4-eicosanetriol( 12),(2S,2'R,3R,4E,8E)-N-2'- Hydroxytetradecanoyl-2-amino-9-methyl-4,8-octadecaa-diene-1,3-diol(13),鲨肝醇(14),十六烷基甘油醚(15),三油酸甘油酯(16)和4-hydroxy-2,3-dimetlhy1-2-nonen-4-olide(17).

Chemical Constituents of South China Sea Gorgonian Melitodes squarnata Nutting

Seventeen compounds were isolated by silica gel column,sephadex LH-20 and HPLC chromatograph,and their structures were identified to be malonganenone E(1),malonganenone D(2),nuttingin A(3),adenosine(4),1,3,7-trimethyl-xanthine(5),2′-deoxythymidine(6),3-methyl-6-hypoxanthine(7),2′-deoxyuridine(8),(22E,24R)-ergosta-8(14),22-dien-3β,5α,6β,7α-tetrol(9),(22E)-cholest-5,22-dien-3β-ol(10),cholesterol(11),(2S,3S,4R)-N-hexadecanoyl)-2-amino-1,3,4-eicosanetriol(12),(2S,2′R,3R,4E,8E)-N-2′-hydroxytetradecanoyl-2-amino-9-methyl-4,8-octadecaadiene-1,3-diol(13),batyl alcohol(14),cetyl glycerin ether(15),glycerol trioleate(16),and hydroxy-2,3-dimethyl-2-nonen-4-olide(17) on the basis of spectroscopic analysis and comparison with literatures..