| 血管内皮生长因子在大鼠骨折骨痂中的表达及意义（简报） |
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| 引用本文： | 李长有,梁德勇,范广宇,宋今丹.血管内皮生长因子在大鼠骨折骨痂中的表达及意义（简报）[J].实验生物学报,2005,38(4):359-362. |
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| 作者姓名： | 李长有 梁德勇 范广宇 宋今丹 |
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| 作者单位： | [1]中国医科大学附属第一医院骨科,沈阳110001 [2]中国医科大学卫生部细胞生物学重点实验室,沈阳110001 |
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| 摘 要： | 骨折愈合是一个独特的多步骤过程，最终可导致正常的骨的解剖和骨的功能的恢复，而不像其他组织修复过程往往最终以瘢痕组织结束。骨折后形成大量修复性骨痂组织，包绕骨折部位。骨痂中存在两种骨形成方式：即膜内化骨和软骨内化骨。系统激素和局部生长因子参与调节骨折愈合过程中的膜内化骨、软骨形成和软骨内化骨。
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| 关 键 词： | 血管内皮生长因子 大鼠 骨折 骨痂 表达 骨折愈合 |
| 收稿时间： | 2004-10-18 |
| 修稿时间： | 2004-10-18 |
THE EXPRESSION OF VEGF IN RAT FRACTURE REPARATIVE CALLUS |
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| Li ChangYou;Liang DeYong;Fan GuangYu;Song JinDan.THE EXPRESSION OF VEGF IN RAT FRACTURE REPARATIVE CALLUS[J].Acta Biologiae Experimentalis Sinica,2005,38(4):359-362. |
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| Authors: | Li ChangYou;Liang DeYong;Fan GuangYu;Song JinDan |
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| Institution: | Department of Orthopaedic Surgery, Ist Hospital, China Medical University, Shenyang 110001, China. cyli@mail.cmu.edu.cn |
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| Abstract: | The present study has determined the histological changes, VEGF (Vascular endothelial growth factor) mRNA alternative expressions and VEGF mRNA levels in chondrogenic-callus, osteogenic-callus and total callus by histology, RT-PCR and Northern blot during rat fracture repair. The results showed that the cellular events of intramembranous ossification, chodrogenesis and endochondral ossification appeared in the callus simultaneously and sequentially. The VEGF mRNAs were expressed in the osteogenic-callus and the chondrogenic-callus, and the strongest expressions were VEGF120 and VEGF164 mRNA. The VEGF mRNA levels in the total callus increased with time after fracture. Take together, these findings suggest that osteogenesis-derived VEGF may play a potential role to modulate the differentiation process of osteogenic and chondrogenic cells during fracture repair. |
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| Keywords: | Fracture Callus VEGF Rat |
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