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人胎脾细胞IL—2和IL—6的产生及其与NK功能发育的关系
引用本文:路力生,崔正言.人胎脾细胞IL—2和IL—6的产生及其与NK功能发育的关系[J].实验生物学报,1992,25(4):305-309.
作者姓名:路力生  崔正言
摘    要:

关 键 词:自然杀伤细胞  白细胞介素  人胎脾

The production of IL-2, IL-6 in relation to the functional development of NK cells in human fetal spleens]
L S Lu,Z Y Cui,Z G Tian.The production of IL-2, IL-6 in relation to the functional development of NK cells in human fetal spleens][J].Acta Biologiae Experimentalis Sinica,1992,25(4):305-309.
Authors:L S Lu  Z Y Cui  Z G Tian
Institution:Department of Immunology, Shandong Academy of Medical Sciences, Jinan.
Abstract:The production of IL-2, IL-6 by fetal splenic mononuclear cells (FSMC) and relationship between them and the ontogenetic development of natural killer cell function were studied in human fetal spleens. As a results, before 20 weeks of gestation, both IL-2 and NK cell activities were not measured, but IL-6 was done. It was found that IL-2, IL-6 and NK cell activities were increased with the gestational age, and shown that there were linear positive correlation between the activities of three ones above (r > 0.86). Before the birth, the induced IL-2 activity was the same as adult levels (p > 0.05), although both IL-6 production and NK activity in fetal spleens were significantly lower than that in adults (p < 0.01). Lastly, the production of IL-2, IL-6 in relation to the functional development of NK cells during the embryonic development was discussed.
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