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天花粉蛋白引起敏感细胞膜上G蛋白激活的初步研究
引用本文:吴振华,柯一保.天花粉蛋白引起敏感细胞膜上G蛋白激活的初步研究[J].实验生物学报,1999,32(2):151-156.
作者姓名:吴振华  柯一保
摘    要:

关 键 词:天花粉蛋白  敏感细胞膜  G蛋白激活

Activation of G protein on the membrane of TCS-sensitive cells]
Z H Wu,H L Nie,B Lu,Q Wang,Y B Ke.Activation of G protein on the membrane of TCS-sensitive cells][J].Acta Biologiae Experimentalis Sinica,1999,32(2):151-156.
Authors:Z H Wu  H L Nie  B Lu  Q Wang  Y B Ke
Institution:Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031.
Abstract:Trichosanthin (TCS), a Type I Ribosome Inactivating Protein isolated from the root tuber of Trichosanthes Kirilowii M. has various biological activities including abortion induction, anti-tumor and anti-HIV. The mechanism of TCS specifically killing sensitive cells has not been studied clearly. In this study, we initially found that there exists TCS-affinity molecule on Syncytiotrophoblast cells and Jar cells. Furthermore, by 35S]GTP gamma S Binding Assay, we find that TCS can activate G protein on the membrane of TCS-sensitive cells. These results indicate that on the membrane of TCS-sensitive cells exists TCS-specific receptor.
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