| 细菌与噬菌体的相互抵抗作用机制 |
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| 引用本文： | 李擎天,郭晓奎.细菌与噬菌体的相互抵抗作用机制[J].微生物与感染,2020,15(5):265-270. |
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| 作者姓名： | 李擎天 郭晓奎 |
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| 作者单位： | 1. 上海交通大学医学院检验系，上海 200025; 2. 上海交通大学医学院全球健康学院，上海 200025 |
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| 基金项目： | 上海市科委兽医生物技术重点实验室开放课题（klab201715） |
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| 摘 要： | 噬菌体是地球生物圈里数量最多、存在最久的个体之一，也是应对抗生素耐药细菌感染的极具特点的候选制剂之一。本文分别以细菌和噬菌体的视角，从阻止噬菌体吸附、超感染排除、限制修饰系统、CRISPRCas、流产感染等方面综述了细菌抗噬菌体的机制以及噬菌体针对细菌抗性机制的应变。
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| 关 键 词： | 细菌 噬菌体 超感染排除 限制修饰 CRISPR Cas 流产感染 |
The phageresistance mechanisms of bacteria and the corresponding responses in bacteriophages |
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| LI Qingtian,GUO Xiaokui.The phageresistance mechanisms of bacteria and the corresponding responses in bacteriophages[J].Journal of Microbes and Infection,2020,15(5):265-270. |
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| Authors: | LI Qingtian GUO Xiaokui |
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| Institution: | 1. Department of Laboratory Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2. Institute for Global Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China |
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| Abstract: | Bacteriophage is one of the most abundant and longstanding individuals in the biosphere of the earth. Bacteriophage is also one of the most characteristic candidates to deal with antibiotic resistant bacterial infections. In this paper, we discussed the phageresistance mechanism of bacteria and bacteriophages’ responses from the aspects of bacteria and phages interactions, such as inhibition of the bacteriophage adsorption, super infection exclusion, restriction modification system, CRISPRCas, and abortive infection. |
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| Keywords: | Bacteria Bacteriophage Super infection exclusion Restriction modification CRISPRCas Abortive infection |
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