| 乙型肝炎病毒核心蛋白变构调节剂的研究进展 |
| |
| 引用本文： | 陈诗琦,毛日成,张继明.乙型肝炎病毒核心蛋白变构调节剂的研究进展[J].微生物与感染,2020,15(5):322-330. |
| |
| 作者姓名： | 陈诗琦 毛日成 张继明 |
| |
| 作者单位： | 复旦大学附属华山医院感染科，上海 200040 |
| |
| 基金项目： | 国家自然科学基金(81670528、81672009、81871640)，上海市浦江人才计划(17PJD005) |
| |
| 摘 要： | 由于乙型肝炎病毒(hepatitis B virus，HBV)的共价闭合环状DNA的持续存在和病毒介导的宿主免疫反应钝化，导致慢性乙型肝炎病毒感染很难治愈。现有的核苷(酸)类似物或聚乙二醇干扰素疗法难以实现高比率的HBV表面抗原清除。目前正在研发的核心蛋白变构调节剂有望大幅度降低血清表面抗原。本文就HBV核心蛋白的结构、功能以及核心蛋白变构调节剂的分类、应用前景等方面进行综述。
|
| 关 键 词： | 乙型肝炎病毒 核心蛋白变构调节剂 共价闭合环状DNA |
Research of hepatitis B virus core protein’s allosteric modulators |
| |
| CHEN Shiqi,MAO Richeng,ZHANG Jiming.Research of hepatitis B virus core protein’s allosteric modulators[J].Journal of Microbes and Infection,2020,15(5):322-330. |
| |
| Authors: | CHEN Shiqi MAO Richeng ZHANG Jiming |
| |
| Institution: | Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China |
| |
| Abstract: | Chronic hepatitis B virus infection is difficult to cure due to the persistence of covalently closed circular DNA and viral-mediated inactivation of host immune responses. Existing nucleoside (acid) analogs or pegylated interferon therapy are difficult to achieve a high ratio of HBV surface antigen clearance. This article reviews the structure and function of HBV core protein, the classification and application prospects of core protein allosteric modulators. |
| |
| Keywords: | Hepatitis B virus Core protein allosteric modulator Covalently-closed-circular DNA |
|
| 点击此处可从《微生物与感染》浏览原始摘要信息 |
| 点击此处可从《微生物与感染》下载免费的PDF全文 |
