| 自然杀伤T细胞抗胞内菌感染的研究进展 |
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| 引用本文： | 孔晓明,刘勇.自然杀伤T细胞抗胞内菌感染的研究进展[J].微生物与感染,2011,6(4):248-251. |
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| 作者姓名： | 孔晓明 刘勇 |
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| 作者单位： | 蚌埠医学院微生物学教研室,安徽省感染与免疫重点实验室,蚌埠233030 |
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| 摘 要： | 自然杀伤T细胞(NKT细胞)是免疫细胞中一类具有特定标记的T细胞亚群,能特异性识别南抗原呈递细胞表面CD1d分子所呈递的糖脂类抗原.活化后的NKT细胞能分泌多种细胞因子,参与机体的天然免疫和获得性免疫反应,还能直接杀伤靶细胞,具有效应细胞的功能.研究发现,NKT细胞在抗胞内菌感染中发挥着重要作用.
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| 关 键 词： | 自然杀伤T细胞 CD1d 胞内菌 抗感染免疫 |
Research progress on natural killer T cells in host defence against intracellular bacterial infectious diseases |
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| KONG Xiao-Ming,LIU Yong.Research progress on natural killer T cells in host defence against intracellular bacterial infectious diseases[J].Journal of Microbes and Infection,2011,6(4):248-251. |
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| Authors: | KONG Xiao-Ming LIU Yong |
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| Institution: | KONG Xiao-Ming,LIU Yong Department of Microbiology and Parasitology,Anhui Key Laboratory of Infection and Immunity,Bengbu Medical College,Bengbu 233030,China |
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| Abstract: | Natural killer T cells (NKT cells) are a unique subset of mature T lymphocytes that can recognize glycolipids presented by CDld molecules expressed on antigen-presenting cells through cell recognition pathway. After activation, NKT cells can secrete large amounts of cytokines, which play important roles in innate and acquired immune responses. NKT cells can also act as direct effector cells via cytolysis or granulysin. Studies have shown that NKT cells play an important role in anti-intracellular bacterial ... |
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| Keywords: | Natural killer T cell CD1d Intracellular bacteria Anti-infectious immunity |
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