| 杆菌细胞形变的机制与功能 |
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| 引用本文： | 王蕾,邹琳,李梦洁,侯琳琳,陈小明,刘伟,孙桂芹,陈力.杆菌细胞形变的机制与功能[J].微生物与感染,2019,14(2):99-105. |
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| 作者姓名： | 王蕾 邹琳 李梦洁 侯琳琳 陈小明 刘伟 孙桂芹 陈力 |
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| 作者单位： | 复旦大学基础医学院医学分子病毒学教育部/卫生部重点实验室,上海,200032;浙江省水利水电装备表面工程技术研究重点实验室,浙江杭州,310024;浙江中医药大学医学技术学院,浙江杭州,310053 |
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| 基金项目： | 国家新药创制重大专项(2014ZX09101-046-004)，国家自然科学基金(31600644)，浙江省水利水电装备表面工程技术研究重点实验室开放基金(2017SLKL004) |
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| 摘 要： | 细菌的形态是细菌分类与鉴定的核心指标。虽然在分类上细菌的基本形态有球形、杆状、弧形和螺旋形,但在不同生理和病理条件下细菌的形态会发生改变。本文对细菌的基本形态转变和杆菌的丝状形变分子机制进行了概述,并归纳了在营养缺乏、放射污染、对抗宿主免疫系统和抗生素处理等条件下细菌产生形态改变的生物学及临床意义。
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| 关 键 词： | 形变 丝状形变 逃逸宿主免疫系统 抗生素耐药 |
Morphological transformation of rod-shaped bacterial cells: mechanisms and biological impacts |
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| WANG Lei,ZOU Lin,LI Mengjie,HOU Linlin,CHEN Xiaoming,LIU Wei,SUN Guiqin,CHEN Li.Morphological transformation of rod-shaped bacterial cells: mechanisms and biological impacts[J].Journal of Microbes and Infection,2019,14(2):99-105. |
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| Authors: | WANG Lei ZOU Lin LI Mengjie HOU Linlin CHEN Xiaoming LIU Wei SUN Guiqin CHEN Li |
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| Institution: | 1. Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; 2. Key Laboratory of Research on Hydraulic and Hydro-Power Equipment Surface Engineering Technology of Zhejiang Province, Hangzhou 310024, Zhejiang Province, China; 3. College of Medical Technology, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China |
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| Abstract: | Cell shape is a basic core feature for bacterial classification and identification. Although a bacterium could be defined as coccus, bacillus, vibrio or spirochete, morphological transformations were observed under various physiological and pathological conditions. In this paper, the molecular mechanisms of rod-shaped bacterial morphological transformation are reviewed, and the biological impacts of morphological transformation under nutritional deficiency, radiation, antibiotic treatment and attacking by host immune systems are discussed. |
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| Keywords: | Morphological transformation Filamentation Escape from host immune system Antibioticresistance |
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