Tumor extracellular acidity-activated nanoparticles as drug delivery systems for enhanced cancer therapy |
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| Authors: | Jin-Zhi Du Cheng-Qiong Mao You-Yong Yuan Xian-Zhu Yang Jun Wang |
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| Institution: | 1. Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, PR China;2. Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, PR China |
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| Abstract: | pH-responsive nanoparticles (NPs) are currently under intense development as drug delivery systems for cancer therapy. Among various pH-responsiveness, NPs that are designed to target slightly acidic extracellular pH environment (pHe) of solid tumors provide a new paradigm of tumor targeted drug delivery. Compared to conventional specific surface targeting approaches, the pHe-targeting strategy is considered to be more general due to the common occurrence of acidic microenvironment in solid tumors. This review mainly focuses on the design and applications of pHe-activated NPs, with special emphasis on pHe-activated surface charge reversal NPs, for drug and siRNA delivery to tumors. The novel development of NPs described here offers great potential for achieving better therapeutic effects in cancer treatment. |
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| Keywords: | Nanoparticles Cancer therapy Drug delivery Surface charge reversal Tumor extracellular acidity responsive |
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