Vascular smooth muscle cell proliferation as a therapeutic target. Part 2: Natural products inhibiting proliferation |
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| Authors: | Pavel Uhrin Dongdong Wang Andrei Mocan Birgit Waltenberger Johannes M Breuss Devesh Tewari Judit Mihaly-Bison Łukasz Huminiecki Rafał R Starzyński Nikolay T Tzvetkov Jarosław Horbańczuk Atanas G Atanasov |
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| Institution: | 1. Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Schwarzspanierstrasse 17, Vienna 1090, Austria;2. Department of Molecular Biology, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, ul. Postepu 36A, Magdalenka 05552, Poland;3. Department of Pharmacognosy, University of Vienna, Althanstrasse 14, Vienna 1090, Austria;4. Institute of Clinical Chemistry, University Hospital Zurich, Wagistrasse 14, Schlieren 8952, Switzerland;5. Department of Pharmaceutical Botany, \"Iuliu Hatieganu\" University of Medicine and Pharmacy, Strada Victor Babe? 8, Cluj-Napoca 400012, Romania;6. ICHAT and Institute for Life Sciences, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Calea M?n??tur 3-5, Cluj-Napoca 400372, Romania;g. Institute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, Innsbruck 6020, Austria;h. Department of Pharmaceutical Sciences, Faculty of Technology, Kumaun University, Nainital, Uttarakhand 263136, India;i. Pharmaceutical Institute, University of Bonn, An der Immenburg 4, Bonn 53121, Germany;j. NTZ Lab Ltd., Krasno Selo 198, Sofia 1618, Bulgaria |
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| Abstract: | Many natural products have been so far tested regarding their potency to inhibit vascular smooth muscle cell proliferation, a process involved in atherosclerosis, pulmonary hypertension and restenosis. Compounds studied in vitro and in vivo as VSMC proliferation inhibitors include, for example indirubin-3′-monoxime, resveratrol, hyperoside, plumericin, pelargonidin, zerumbone and apamin. Moreover, taxol and rapamycin, the most prominent compounds applied in drug-eluting stents to counteract restenosis, are natural products. Numerous studies show that natural products have proven to yield effective inhibitors of vascular smooth muscle cell proliferation and ongoing research effort might result in the discovery of further clinically relevant compounds. |
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| Keywords: | Atherosclerosis Drug-discovery Molecular target Natural products Restenosis Signaling pathway Vascular smooth muscle cell proliferation |
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