Dietary nutraceuticals as backbone for bone health |
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Authors: | Manoj K Pandey Subash C Gupta Deepkamal Karelia Patrick J Gilhooley Mehdi Shakibaei Bharat B Aggarwal |
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Institution: | 1. Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ, USA;2. Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, India;3. Department of Pharmacology, Penn State College of Medicine, Hershey, PA, USA;4. Musculoskeletal Research Group and Tumour Biology, Chair of Vegetative Anatomy, Institute of Anatomy, Ludwig-Maximilian-University, Munich, Germany;5. Inflammation Research Center, San Diego, CA, USA |
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Abstract: | Bone loss or osteoporosis, is a slow-progressing disease that results from dysregulation of pro-inflammatory cytokines. The FDA has approved number of drugs for bone loss prevention, nonetheless all are expensive and have multiple side effects. The nutraceuticals identified from dietary agents such as butein, cardamonin, coronarin D curcumin, diosgenin, embelin, gambogic acid, genistein, plumbagin, quercetin, reseveratrol, zerumbone and more, can modulate cell signaling pathways and reverse/slow down osteoporosis. Most of these nutraceuticals are inexpensive; show no side effect while still possessing anti-inflammatory properties. This review provides various mechanisms of osteoporosis and how nutraceuticals can potentially prevent the bone loss. |
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Keywords: | Phytoestrogens Bone loss Nutraceuticals Osteoclastogenesis Bone remodeling Osteoporosis Pro-inflammatory cytokines |
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