Down-regulation of kallikrein-related peptidase 5 (<Emphasis Type="Italic">KLK5</Emphasis>) expression in breast cancer patients: a biomarker for the differential diagnosis of breast lesions |
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| Authors: | Margaritis Avgeris Georgia Papachristopoulou Athanasios Polychronis Andreas Scorilas |
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| Institution: | (1) Department of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, 15701 Athens, Greece;(2) Oncological Hospital “G.Gennimatas” IKA-ETAM of Athens, Asopiou 4, 11473 Athens, Greece |
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| Abstract: | Background Kallikrein-related peptidase 5 (KLK5) is a secreted trypsin-like protease of the KLK family, encoded by the KLK5 gene. KLK5 has been found to cleave various extracellular matrix components, as well as to activate several other KLK proteases,
triggering the stimulation of tissue microenvironment proteolytic cascades. |
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| Keywords: | KLK5 Breast Cancer Cancer Biomarkers Tumor Markers KLKs Kallikreins Serine Proteases Proteolysis |
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