Mesenchymal stromal cells ameliorate acute allergic rhinitis in rats |
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| Authors: | Chunlei Li Yanxia Fu Yinyin Wang Yanhua Kong Mengdi Li Danhui Ma Wanli Zhai Hao Wang Yuting Lin Sihan Liu Fangli Ren Jun Li Yi Wang |
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| Affiliation: | 1. Graduate School of Beijing University of Chinese Medicine, Clinical Medical School of Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China;2. National Clinical Research Center of Respiratory Diseases, Center for Respiratory Diseases China‐Japan Friendship Hospital, The 2nd Pulmonary Department of TCM, The Key Institute of State Administration of Traditional Chinese Medicine (Pneumonopathy Chronic Cough and Dyspnea), Beijing Key Laboratory (no BZ0321), China‐Japan Friendship Hospital, Beijing, China;3. State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China;4. Institute of Immunology, Medical School, Third Military Medical University, Chongqing, China |
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| Abstract: | Mesenchymal stromal cells (MSCs) have been extensively investigated as a potential antiinflammatory treatment in many inflammatory‐related diseases; however, it remains unclear whether MSCs could be used to treat acute allergic rhinitis. A rat model of allergic rhinitis was treated with MSCs. The effect of MSCs on the inflammation of allergic rhinitis was evaluated by sneezing, nose rubbing, the pathology of the nasal mucosa, and the expression of interleukin 4, tumour necrosis factor alpha, and immunoglobulin E in the serum of rats. Also, the population of MSCs isolated from umbilical cords of humans was evaluated to determine if they could inhibit the symptoms and inflammation of acute allergic rhinitis in a rat model. We observed that this population of cells inhibited sneezing, nose rubbing, and changes in the pathology of the nasal mucosa. Intriguingly, we observed that MSCs reduced the expression of interleukin 4, tumour necrosis factor alpha, and immunoglobulin E in the serum. Furthermore, MSCs reduced the expression of histamine and the recruitment of macrophages in the nasal mucosa of allergic rhinitis rats. We reasoned that the effect of MSCs on allergic rhinitis might be through its regulation of the secretion of related cytokines from macrophages during the process of acute allergic rhinitis. This work suggested that MSCs from the umbilical cords of humans could be used as a positive clinical therapy for the human disease. |
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| Keywords: | allergic rhinitis antiinflammation cytokine mesenchymal stromal cells umbilical cord |
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