ENZYMES OF THE γ-GLUTAMYL CYCLE IN THE CHOROID PLEXUS AND BRAIN |
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| Authors: | P. Obiekwe Okonkwo Marian Orlowski J. P. Green |
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| Affiliation: | Department of Pharmacology, Mount Sinai School of Medicine of the City University of New York, New York, NY 10029, U.S.A. |
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| Abstract: | —The presence of enzymes of the γ-glutamyl cycle in the bovine and rabbit brain and choroid plexus is described. The activities of γ-glutamyl transpeptidase, γ-glutamyl cyclotransferase and γ-glutamyl-cysteine synthetase in the choroid plexus were found to be higher than in the brain. The activity of γ-glutamyl transpeptidase in the choroid plexus was many times higher than the activity of the other enzymes. Brain and choroid plexus γ-glutamyl transpeptidase were activated by Na+ and K+. Both brain and choroid plexus showed only a very limited capacity to metabolize [14C]5-oxoproline to 14CO2. |
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