Surface changes in differentiating Friend erythroleukemic cells in culture. |
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Authors: | H Eisen S Nasi C P Georgopoulos D Arndt-Jovin W Ostertag |
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Affiliation: | Département de Biologie Moléculaire Université de Genève Genève, Switzerland;Abteilung Molekulare Biologie Max-Planck-Institut für Biophysikalische Chemie 34 — Göttingen, Federal Republic of Germany;Abteilung Molekulare Biologie Max-Planck-Institut für Experimentelle Medizin 34 — Göttingen, Federal Republic of Germany |
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Abstract: | The sensitivity to agglutination by several plant lectins has been studied during the induced erythroid differentiation of Friend erythroleukemic cells in culture. In addition, the number of lectin receptors on the cell has been measured. It is shown that early during the differentiation, there is an increase in agglutinability while the receptor density remains constant. In the later phase of the differentiation process, the cells lose their sensitivity to agglutination while the receptor number and density increases. These changes were not observed on nonerythroid mastocytoma culture cells. Two nondifferentiating variants of the FL cells were shown to have altered sensitivities to agglutination by ConA. |
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